In the summer of 1918, a number of the citizens of Campbellton realized the hospital accommodations were inadequate. Also, a suitable memorial was needed to commemorate the memory of the brave lads of the Restigouche and Bay Chaleur District who had made the supreme sacrifice in the First World War. A meeting was held to discuss the construction of a new hospital to serve the double purpose.

On July 1, 1920, at a ceremony led by Lieutenant-Colonel Alexander McMillan, DSO, the corner stone of the hospital was laid in the presence of over 2,000 people. The Restigouche and Bay Chaleur Soldiers' Memorial Hospital was formally opened on March 16, 1922.

The Campbellton Regional Hospital opened its doors in 1991, following the amalgamation of the Soldiers’ Memorial Hospital and Hôpital Hôtel-Dieu and Soldiers' Memorial Hospital was converted into the Soldiers Memorial Villa.