On May 17, 1949, Huntsville District Memorial Hospital opened on Mill Street, operated by the Canadian Red Cross. It was dedicated to the memory of Veterans of the First and Second World Wars. Three years later, the Red Cross handed over control of the Huntsville District Memorial Hospital to the Huntsville Hospital Corporation.

By the 1970s , the hospital needed to expand and a new site was chosen. On June 2, 1978, Huntsville District Memorial Hospital opened at 100 Frank Miller Drive.